| Q1 | Ema Mravcova (RICE) def. Diana Kaibara (UTA) 6-3, 6-1 |
| Q2 | Elena Mireles (SMU) def. Ema Mravcova (RICE) 6-3, 6-4 |
| Q1 | Valentina Ponce (RICE) def. Luciana Paez (UIW) 4-6, 6-0, 6-3 |
| Q2 | Anna Perelman (TAMU) def. Valentina Ponce (RICE) 6-1, 6-4 |
| Q1 | Daniela Chica (RICE) def. Milic Milosavljevic (UTSA) 6-1, 6-1 |
| Q2 | Daniela Chica (RICE) def. Jemma Cave (SFA) 5-7, 6-4, 7-6 |
| 64 | Cristi Ramos Sierra (TCU) def. Daniela Chica (RICE) 4-6, 6-1, 6-1 |
| 64 | Estefania Gonzalez (UIW) def. Anushka Ashar (RICE) 7-5, 6-4 |
| 64 | Nithesa Selvaraj (RICE) def. Valeriia Krokhotina (HOUSTON) 6-4, 6-3 |
| 64 | Ksenia Mamontova (SFA) def. Francesca Maguina (RICE) 7-5, 6-3 |
| 64 | Darya Schwartzman (RICE) def. Masha Vrsalovic (ACU) 6-4, 6-3 |
| 64 | Divna Ratkovic (RICE) def. Tomi Main (TCU) 6-1, 6-1 |
| 64 | Uma Bakaityte (RICE) def. Duru Kuscu (TARLETON) 6-4, 7-5 |
| 32 | Nithesa Selvaraj (RICE) def. Addison YangComiskey (SMU) 6-2, 7-6 |
| 32 | Darya Schwartzman (RICE) def. Emma Persson (TARLETON) 6-0, 4-6, 6-3 |
| 32 | Divna Ratkovic (RICE) def. Violeta Martinez (TAMU) 6-3, 7-5 |
| 32 | Uma Bakaityte (RICE) def. Kennedy Gibbs (BAYLOR) 6-3, 2-6, 6-3 |
| C32 | Nithesa Selvaraj (RICE) def. Ximena Araneda (TARLETON) 6-2, 7-6 |
| C32 | Francesca Maguina (RICE) def. Petja Drame (HOUSTON) 6-1, 6-2 |
| C32 | Anushka Ashar (RICE) def. Ximena Araneda (TARLETON) 6-4, 6-0 |
| C32 | Daniela Chica (RICE) def. Maria Castano (TARLETON) 6-1, 6-4 |
| C16 | Arina Oreshchenkova (TTECH) def. Daniela Chica (RICE) 6-2, 6-4 |
| C16 | Sophie Schouten (HOUSTON) def. Anushka Ashar (RICE) 3-6, 6-2, 10-4 |
| C16 | Francesca Maguina (RICE) def. Ella Brownback (TTECH) 4-6, 6-3, 10-5 |
| 16 | Nithesa Selvaraj (RICE) def. Yekaterina Dmitriche (TTECH) 6-3, 4-6, 7-6 |
| 16 | Darya Schwartzman (RICE) def. Salma Drugdova (TEXAS) 7-6, 6-4 |
| 16 | Hailey Murphy (TTECH) def. Divna Ratkovic (RICE) 6-0, 6-2 |
| 16 | Yu-Chin Tsai (TCU) def. Uma Bakaityte (RICE) 6-4, 6-2 |
| QF | Raquel Chica (TCU) def. Nithesa Selvaraj (RICE) 7-5, 6-3 |
| QF | Darya Schwartzman (RICE) def. Daria Smetannikov (TAMU) 2-6, 6-1, 6-4 |
| C8 | Francesca Maguina (RICE) def. Elena Mireles (SMU) 2-6, 7-6, 10-4 |
| SF | Darya Schwartzman (RICE) def. Hailey Murphy (TTECH) 6-2, 6-4 |
| CSF | Francesca Maguina (RICE) def. Tomi Main (TCU) 6-1, 6-1 |
| F | Mia Kupres (TAMU) def. Darya Schwartzman (RICE) 6-4, 6-4 |
| CF | Letizia Corsini (TCU) def. Francesca Maguina (RICE) 6-4, 7-5 |
