| 10/8 | Fernanda Martinez (RICE) def. Jessica Board (ACU) 7-5, 7-6 |
| 10/8 | Daniela Chica (RICE) def. Akari Tomoyose (UTSA) 6-3, 6-0 |
| 10/8 | Josephine Kunz (RICE) def. Celine Absawi (UTSA) 6-2, 6-7, 6-1 |
| 10/8 | Francesca Maguina (RICE) def. Luna Buijtenhuis (UTRGV) 6-2, 3-0, retired |
| 10/8 | Yoana Konstantinova (TAMU) def. Daniela Chica (RICE) 7-6, 6-2 |
| 10/8 | Josephine Kunz (RICE) def. Victoria Franklin (UIW) 6-0, 6-3 |
| 10/8 | Fernanda Martinez (RICE) def. Ligaya Murray (BAYLOR) 6-3, 0-6, 6-3 |
| 64 | Natalie Cinkova (HOUSTON) def. Anushka Ashar (RICE) 3-6, 6-0, 6-3 |
| 64 | Divna Ratkovic (RICE) def. Kaili Teso (TTECH) 6-3, 6-2 |
| 64 | Francesca Maguina (RICE) def. Raegan Farm (TTECH) 6-2, 6-4 |
| 64 | Nithesa Selvaraj (RICE) def. Mariangel Estrella (UTRGV) 3-6, 6-4, 6-1 |
| 64 | Uma Bakaityte (RICE) def. Lou Chalard (UNT) 7-6, 6-3 |
| 64 | Polina Sleptsova (TTECH) def. Josephine Kunz (RICE) 6-1, 4-6, 7-6 |
| 32 | Divna Ratkovic (RICE) def. Allie Bittner (SMU) 6-1, 6-1 |
| 32 | Na Dong (BAYLOR) def. Francesca Maguina (RICE) 2-6, 6-4, 6-3 |
| 32 | Nithesa Selvaraj (RICE) def. Laura Pop (TTECH) 6-2, 7-5 |
| 32 | Uma Bakaityte (RICE) def. Maria Ustic (BAYLOR) 6-3, 7-5 |
| 16 | Divna Ratkovic (RICE) def. Kseniya Ramanouskaya (TAMUCC) 6-1, 6-1 |
| 16 | Kori Montoya (TAMU) def. Nithesa Selvaraj (RICE) 6-2, 6-3 |
| 16 | Sofiia Mykhailets (TCU) def. Uma Bakaityte (RICE) 7-5, 7-6 |
| C1 | Anushka Ashar (RICE) def. Jana Ruzic (UIW) 7-5, 6-2 |
| C1 | Carolina Laydner (UNT) def. Josephine Kunz (RICE) 6-4, 7-6 |
| 8 | Divna Ratkovic (RICE) def. Jennifer Jackson (TTECH) 6-3, 6-2 |
| Polina Sleptsova (TTECH) def. Daniela Chica (RICE) 6-4, 6-3 |
| SF | Divna Ratkovic (RICE) def. Alexander Frusina (TAMU) 6-3, 3-6, 6-3 |
