| Q64 | Anushka Ashar (RICE) def. Ireland Simme (TXST) 6-4, 6-3 |
| Q64 | Valentina Ponce (RICE) def. Juliette Jalai (TAMUCC) 6-3, 6-0 |
| Q64 | Nithesa Selvaraj (RICE) def. Clara Sobius (TARLETON) 6-2, 6-0 |
| Q32 | Anushka Ashar (RICE) def. Gabriela Cortes (UH) 7-6, 6-1, 5-4, retired |
| Q32 | Valentina Ponce (RICE) def. Lou Chalard (UNT) 7-5, 6-4 |
| Q32 | Sofia Fortuno (TXST) def. Nithesa Selvaraj (RICE) 6-2, 6-7, 6-3 |
| 64 | Fernanda Martinez (RICE) def. Na Dong (BAYLOR) 6-0, 6-3 |
| 64 | Divna Ratkovic (RICE) def. Elena Daskalova (TTECH) 6-1, 1-6, 6-0 |
| 64 | Arina Oreshchenkova (TTECH) def. Saara Orav (RICE) 7-6, 6-3 |
| 64 | Darya Schwartzman (RICE) def. Sonja Rooth (SFA) 6-3, 6-1 |
| 32 | Na Dong (BAYLOR) def. Fernanda Martinez (RICE) 2-6, 6-0, 6-3 |
| 32 | Divna Ratkovic (RICE) def. Lexington Reed (TAMUI) 7-6, 2-6, 6-1 |
| 32 | Andreea Lila (TTECH) def. Darya Schwartzman (RICE) 6-2, 7-5 |
| 16 | Vivian Ovrootsky (TEXAS) def. Divna Ratkovic (RICE) 6-0, 6-2 |
| C32Q | Fernanda Martinez (RICE) def. Arina Babenko (UTSA) 6-3, 6-3 |
| C32Q | Yu-Chin Tsai (TCU) def. Valentina Ponce (RICE) 6-1, 6-3 |
| C32Q | Marina Adati (UNT) def. Saara Orav (RICE) 3-6, 4-0, retired |
| C16 | Fernanda Martinez (RICE) def. Millie Skelton (SMU) 6-2, 6-4 |
| CQF | Mariia Hlahola (TTECH) def. Fernanda Martinez (RICE) 7-6, 6-1 |
