| Q1 | Anushka Ashar (RICE) def. A Mukhutdinova (TARLETON) 6-3, 6-2 |
| Q2 | Anushka Ashar (RICE) def. Isid Hernandez (UIW) 6-4, 6-3 |
| 64 | Federica Trevisan (RICE) def. Stanislava Shulzhenk (UNT) 6-2, 6-3 |
| 64 | Emma Persson (TARLETON) def. Chie Kezuka (RICE) 6-2, 7-6 |
| 64 | A Sayfetdinova (TTECH) def. Anushka Ashar (RICE) 6-1, 6-1 |
| 64 | Divna Ratkovic (RICE) def. Vittoria Baccino (UTSA) 6-4, 6-3 |
| 64 | Mariya Polishchuk (TTECH) def. Darya Schwartzman (RICE) 7-6, 6-3 |
| 64 | Metka Komac (TTECH) def. Saara Orav (RICE) 4-6, 7-5, 6-4 |
| 32 | Destinee Martins (TCU) def. Federica Trevisan (RICE) 7-6, 6-4 |
| 32 | Sarina Reinertsen (UTA) def. Divna Ratkovic (RICE) 2-6, 6-2, 6-3 |
| C32 | Chie Kezuka (RICE) def. Felcia Back (SFA) 6-1, 6-2 |
| C32 | Sydney Fitch (TAMU) def. Anushka Ashar (RICE) 6-2, 6-2 |
| C32 | Darya Schwartzman (RICE) def. Emma Aucagne (TAMUCC) 6-1, 6-0 |
| C32 | Sofia Franco Salcedo (UIW) def. Saara Orav (RICE) 6-4, 6-3 |
| C16 | Chie Kezuka (RICE) def. Aleksandra Zlatarova (UTSA) 2-6, 7-5, 10-8 |
| C16 | Darya Schwartzman (RICE) def. Libby Blair (ACU) 6-2, 6-1 |
| CQF | Ana Paula Jimenez (UTA) def. Chie Kezuka (RICE) 6-1, 7-5 |
| CQF | Darya Schwartzman (RICE) def. Maya Makoric (SMU) 6-3, 6-2 |
| CSF | Gianna Pielet (TAMU) def. Darya Schwartzman (RICE) 7-6, 0-6, 11-9 |
